Photo by Cindy Keese

Hotels in Seneca

your current months are January, 2025 and February, 2025.
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February 2025

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Where to stay in Seneca?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top neighborhoods in Seneca

Learn more about Seneca

Seneca, well-known for its sports and university life, features attractions such as Keowee Reservoir and Lake Keowee. This family-friendly city has something for everyone including its waterfront, coffeehouses, and sights like Keowee Key Golf Course and Lake Hartwell.

View from the dike in Clemson, SC. This trail is used by runners, bikers, and lots of dog walkers.
Photo by Cindy Keese
Open Photo by Cindy Keese

Frequently asked questions

What accommodations do travelers like in Seneca?
Where can I find free parking at my hotel in Seneca?
Park your car for free at these properties: Quality Inn Seneca US-123, Hampton Inn & Suites Seneca-Clemson Area, SC and Best Western Seneca-Clemson. There are 5 choices you may want to check out on our site.
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Seneca?
Your animal companion is welcome at these pet-friendly hotels: Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson, and Days Inn by Wyndham Seneca / Clemson Area. There are 7 options you can choose from on our site.
Which Seneca hotels do our guests like for their central location?
Our guests rave about the location of these properties: Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123 are a few accommodations you might want to consider that’ll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 186 vacation homes. In addition, there are 10 apartments and 7 condos.
Where can I stay if I'm traveling to Seneca with my children?
Parents traveling with children may want to consider Fairfield Inn & Suites Seneca Clemson Univ Area and Beautiful Waterfront Retreat on Lake Keowee W/ Clemson game day parking pass .
Where should I stay in Seneca for a trip with my partner?
Beautiful Waterfront Retreat on Lake Keowee W/ Clemson game day parking pass is a great option for a romantic getaway.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.